Breakthrough Material discovered for Detecting Methotrexate Overdosage

Breakthrough Material discovered for Detecting Methotrexate Overdosage


Researchers have introduced a highly fluorescent material that offers a non-enzymatic approach to detect the presence of the anticancer drug Methotrexate (MTX), particularly known for its toxicity at elevated dosages.


GS-02 GS-03 (Science & technology, Health)


  • Material Details: This innovative material, characterized by outstanding optical properties, is crafted from phosphorene, cystine, and gold (Ph-Cys-Au). It serves as an effective visual sensing platform specifically designed for the identification of MTX overdosage.
  • Development Source: Scientists from the Institute of Advanced Study in Science and Technology (IASST), an autonomous institute under the Department of Science and Technology (DST), spearheaded the development of this novel material.


  • Methotrexate (MTX) stands as a widely employed anticancer drug.
  • When its concentration exceeds 10 µM in blood plasma for an extended period, it poses significant health risks, including lung issues, heart complications, and stomach ulcers.
  • The drug’s expensive nature, coupled with the intricacy and time consumption of traditional detection methods, underscores the critical need for swift and sensitive detection through simplified methodologies.
  • This breakthrough material opens new possibilities for efficient and timely monitoring of Methotrexate levels, offering a potential solution to the challenges associated with conventional detection techniques.